Ontology highlight
ABSTRACT:
SUBMITTER: Ferraro M
PROVIDER: S-EPMC6225287 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Ferraro Mariarosaria M Colombo Giorgio G
Molecules (Basel, Switzerland) 20180904 9
Investigating protein-protein interactions (PPIs) holds great potential for therapeutic applications, since they mediate intricate cell signaling networks in physiological and disease states. However, their complex and multifaceted nature poses a major challenge for biochemistry and medicinal chemistry, thereby limiting the druggability of biological partners participating in PPIs. Molecular Dynamics (MD) provides a solid framework to study the reciprocal shaping of proteins' interacting surface ...[more]