Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC6225339 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20181027 44
We report here on three constitutionally isomeric peptides, each of which contains two glutamic acid residues and two lysine residues functionalized with S-aroylthiooximes (SATOs), termed peptide-H<sub>2</sub>S donor conjugates (PHDCs). SATOs decompose in the presence of cysteine to generate hydrogen sulfide (H<sub>2</sub>S), a biological signaling gas with therapeutic potential. The PHDCs self-assemble in aqueous solution into different morphologies, two into nanoribbons of different dimensions ...[more]