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Epigenetic control of innate and adaptive immune memory.


ABSTRACT: Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrates that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate that differentiating and 'memory' NK cells possess distinct chromatin accessibility states and that their epigenetic profiles reveal a 'poised' regulatory program at the memory stage. Furthermore, we elucidate how individual STAT transcription factors differentially control epigenetic and transcriptional states early during infection. Finally, concurrent chromatin profiling of the canonical CD8+ T cell response against the same infection demonstrated parallel and distinct epigenetic signatures defining NK cells and CD8+ T cells. Overall, our study reveals the dynamic nature of epigenetic modifications during the generation of innate and adaptive lymphocyte memory.

SUBMITTER: Lau CM 

PROVIDER: S-EPMC6225771 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Epigenetic control of innate and adaptive immune memory.

Lau Colleen M CM   Adams Nicholas M NM   Geary Clair D CD   Weizman Orr-El OE   Rapp Moritz M   Pritykin Yuri Y   Leslie Christina S CS   Sun Joseph C JC  

Nature immunology 20180806 9


Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrates that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate that differentiating and 'memory' NK cells possess distinct chromatin accessibility states and that their epigenetic profiles reveal a 'poised' regulatory program at the memory stage  ...[more]

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