Ontology highlight
ABSTRACT:
SUBMITTER: Lau CM
PROVIDER: S-EPMC6225771 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Lau Colleen M CM Adams Nicholas M NM Geary Clair D CD Weizman Orr-El OE Rapp Moritz M Pritykin Yuri Y Leslie Christina S CS Sun Joseph C JC
Nature immunology 20180806 9
Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrates that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate that differentiating and 'memory' NK cells possess distinct chromatin accessibility states and that their epigenetic profiles reveal a 'poised' regulatory program at the memory stage ...[more]