Ontology highlight
ABSTRACT:
SUBMITTER: Kellogg EH
PROVIDER: S-EPMC6225777 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20180510 6394
Tau is a developmentally regulated axonal protein that stabilizes and bundles microtubules (MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent aggregation into fibrils implicated in Alzheimer's disease. It is unclear which tau residues are crucial for tau-MT interactions, where tau binds on MTs, and how it stabilizes them. We used cryo-electron microscopy to visualize different tau constructs on MTs and computational approaches to generate atomic models of tau- ...[more]