Ontology highlight
ABSTRACT:
SUBMITTER: Majed H
PROVIDER: S-EPMC6225992 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Majed Hiwa H Johnston Tatiana T Kelso Celine C Monachino Enrico E Jergic Slobodan S Dixon Nicholas E NE Mylonakis Eleftherios E Kelso Michael J MJ
Bioorganic & medicinal chemistry letters 20181003 22
Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of serious hospital-acquired infections and is responsible for significant morbidity and mortality in residential care facilities. New agents against MRSA are needed to combat rising resistance to current antibiotics. We recently reported 5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC) as a new bacteriostatic agent against MRSA that appears to act via a novel mechanism. Here, twenty nine analogs of HMPC were synt ...[more]