Cog4 is required for protrusion and extension of the epithelium in the developing semicircular canals.
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ABSTRACT:
SUBMITTER: Clement A
PROVIDER: S-EPMC6226009 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
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Cog4 is required for protrusion and extension of the epithelium in the developing semicircular canals.
Clément Aurélie A Blanco-Sánchez Bernardo B Peirce Judy L JL Westerfield Monte M
Mechanisms of development 20181001
The semicircular canals in the inner ear sense angular acceleration. In zebrafish, the semicircular canals develop from epithelial projections that grow toward each other and fuse to form pillars. The growth of the epithelial projections is driven by the production and secretion of extracellular matrix components by the epithelium. The conserved oligomeric Golgi 4 protein, Cog4, functions in retrograde vesicle transport within the Golgi and mutations can lead to sensory neural hearing loss. In z ...[more]
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