Ontology highlight
ABSTRACT:
SUBMITTER: Brown A
PROVIDER: S-EPMC6226290 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Brown Alan A Baird Matthew R MR Yip Matthew Cj MC Murray Jason J Shao Sichen S
eLife 20181024
The cellular levels and activities of ribosomes directly regulate gene expression during numerous physiological processes. The mechanisms that globally repress translation are incompletely understood. Here, we use electron cryomicroscopy to analyze inactive ribosomes isolated from mammalian reticulocytes, the penultimate stage of red blood cell differentiation. We identify two types of ribosomes that are translationally repressed by protein interactions. The first comprises ribosomes sequestered ...[more]