Intron retention is a source of neoepitopes in cancer.
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ABSTRACT:
SUBMITTER: Smart AC
PROVIDER: S-EPMC6226333 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Intron retention is a source of neoepitopes in cancer.
Smart Alicia C AC Margolis Claire A CA Pimentel Harold H He Meng Xiao MX Miao Diana D Adeegbe Dennis D Fugmann Tim T Wong Kwok-Kin KK Van Allen Eliezer M EM
Nature biotechnology 20180816 11
We present an in silico approach to identifying neoepitopes derived from intron retention events in tumor transcriptomes. Using mass spectrometry immunopeptidome analysis, we show that retained intron neoepitopes are processed and presented on MHC I on the surface of cancer cell lines. RNA-derived neoepitopes should be considered for prospective personalized cancer vaccine development. ...[more]
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