Ontology highlight
ABSTRACT:
SUBMITTER: Shihoya W
PROVIDER: S-EPMC6226434 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Shihoya Wataru W Izume Tamaki T Inoue Asuka A Yamashita Keitaro K Kadji Francois Marie Ngako FMN Hirata Kunio K Aoki Junken J Nishizawa Tomohiro T Nureki Osamu O
Nature communications 20181109 1
Endothelin receptors (ET<sub>A</sub> and ET<sub>B</sub>) are class A GPCRs activated by vasoactive peptide endothelins, and are involved in blood pressure regulation. ET<sub>B</sub>-selective signalling induces vasorelaxation, and thus selective ET<sub>B</sub> agonists are expected to be utilized for improved anti-tumour drug delivery and neuroprotection. Here, we report the crystal structures of human ET<sub>B</sub> receptor in complex with ET<sub>B</sub>-selective agonist, endothelin-3 and an ...[more]