Ontology highlight
ABSTRACT:
SUBMITTER: van Wilgenburg B
PROVIDER: S-EPMC6226485 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
van Wilgenburg Bonnie B Loh Liyen L Chen Zhenjun Z Pediongco Troi J TJ Wang Huimeng H Shi Mai M Zhao Zhe Z Koutsakos Marios M Nüssing Simone S Sant Sneha S Wang Zhongfang Z D'Souza Criselle C Jia Xiaoxiao X Almeida Catarina F CF Kostenko Lyudmila L Eckle Sidonia B G SBG Meehan Bronwyn S BS Kallies Axel A Godfrey Dale I DI Reading Patrick C PC Corbett Alexandra J AJ McCluskey James J Klenerman Paul P Kedzierska Katherine K Hinks Timothy S C TSC
Nature communications 20181109 1
Mucosal associated invariant T (MAIT) cells are evolutionarily-conserved, innate-like lymphocytes which are abundant in human lungs and can contribute to protection against pulmonary bacterial infection. MAIT cells are also activated during human viral infections, yet it remains unknown whether MAIT cells play a significant protective or even detrimental role during viral infections in vivo. Using murine experimental challenge with two strains of influenza A virus, we show that MAIT cells accumu ...[more]