Fibroblast growth factor-2, but not the adipose tissue-derived stromal cells secretome, inhibits TGF-?1-induced differentiation of human cardiac fibroblasts into myofibroblasts.
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ABSTRACT:
SUBMITTER: Liguori TTA
PROVIDER: S-EPMC6226511 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
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Fibroblast growth factor-2, but not the adipose tissue-derived stromal cells secretome, inhibits TGF-β1-induced differentiation of human cardiac fibroblasts into myofibroblasts.
Liguori Tácia Tavares Aquinas TTA Liguori Gabriel Romero GR Moreira Luiz Felipe Pinho LFP Harmsen Martin Conrad MC
Scientific reports 20181109 1
Transforming growth factor-β1 (TGF-β1) is a potent inducer of fibroblast to myofibroblast differentiation and contributes to the pro-fibrotic microenvironment during cardiac remodeling. Fibroblast growth factor-2 (FGF-2) is a growth factor secreted by adipose tissue-derived stromal cells (ASC) which can antagonize TGF-β1 signaling. We hypothesized that TGF-β1-induced cardiac fibroblast to myofibroblast differentiation is abrogated by FGF-2 and ASC conditioned medium (ASC-CMed). Our experiments d ...[more]
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