Ontology highlight
ABSTRACT:
SUBMITTER: Seternes OM
PROVIDER: S-EPMC6227380 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Seternes Ole-Morten OM Kidger Andrew M AM Keyse Stephen M SM
Biochimica et biophysica acta. Molecular cell research 20180908 1
It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in mammalian cells and tissues. MKPs provide a mechanism of spatiotemporal feedback control of these key signalling pathways, but can also mediate crosstalk between distinct MAP kinase cascades and facilitate interactions between MAP kinase pathways and other key signalling modules. As our knowledge of the regulation, su ...[more]