Dataset Information

Efficacy and safety of antagonists for chemoattractant receptor-homologous molecule expressed on Th2 cells in adult patients with asthma: a meta-analysis and systematic review.

ABSTRACT:

Background

Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonists are novel agents for asthma but with controversial efficacies in clinical trials. Therefore, we conducted a meta-analysis to determine the roles of CRTH2 antagonists in asthma.

Methods

We searched in major databases for RCTs comparing CRTH2 antagonists with placebo in asthma. Fixed- or random-effects model was performed to calculate mean differences (MD), risk ratio (RR) or risk difference (RD) and 95% confidence interval (CI).

Results

A total of 14 trails with 4671 participants were included in our final analysis. Instead of add-on treatment of CRTH2 antagonists to corticosteroids, CRTH2 antagonist monotherapy significantly improved pre-bronchodilator FEV₁ (MD?=?0.09, 95% CI 0.04 to 0.15, P?=?0.0005), FEV₁% predicted (MD?=?3.65, 95% CI 1.15 to 6.14, P?=?0.004), and AQLQ (MD?=?0.25, 95% CI 0.09 to 0.41, P?=?0.002), and reduced asthma exacerbations (RR?=?0.45, 95% CI 0.23 to 0.85, P?=?0.01). Rescue use of SABA was significantly decreased in both CRTH2 antagonist monotherapy (MD?=?-?0.04, 95% CI -0.05 to -?0.03, P?ConclusionsCRTH2 antagonist monotherapy can safely improve lung function and quality of life, and reduce asthma exacerbations and SABA use in asthmatics.

SUBMITTER: Yang J

PROVIDER: S-EPMC6230288 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Publications

Efficacy and safety of antagonists for chemoattractant receptor-homologous molecule expressed on Th2 cells in adult patients with asthma: a meta-analysis and systematic review.

Yang Jing J Luo Jian J Yang Ling L Yang Dan D Wang Dan D Liu Bicui B Huang Tingxuan T Wang Xiaohu X Liang Binmiao B Liu Chuntao C

Respiratory research 20181109 1

<h4>Background</h4>Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonists are novel agents for asthma but with controversial efficacies in clinical trials. Therefore, we conducted a meta-analysis to determine the roles of CRTH2 antagonists in asthma.<h4>Methods</h4>We searched in major databases for RCTs comparing CRTH2 antagonists with placebo in asthma. Fixed- or random-effects model was performed to calculate mean differences (MD), risk ratio (RR) or risk diff ...[more]

PMID: 30413187

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Dataset Information

Efficacy and safety of antagonists for chemoattractant receptor-homologous molecule expressed on Th2 cells in adult patients with asthma: a meta-analysis and systematic review.

Background

Methods

Results

Publications

Efficacy and safety of antagonists for chemoattractant receptor-homologous molecule expressed on Th2 cells in adult patients with asthma: a meta-analysis and systematic review.

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