Ontology highlight
ABSTRACT:
SUBMITTER: Alam MB
PROVIDER: S-EPMC6230386 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Alam Md Badrul MB An Hongyan H Ra Jeong-Sic JS Lim Ji-Young JY Lee Seung-Hyun SH Yoo Chi-Yeol CY Lee Sang-Han SH
Oxidative medicine and cellular longevity 20181028
Glucose absorption from the gut and glucose uptake into muscles are vital for the regulation of glucose homeostasis. In the current study, we determined if gossypol (GSP) reduces postprandial hyperglycemia or enhances glucose uptake; we also investigated the molecular mechanisms underlying those processes <i>in vitro</i> and <i>in vivo</i>. GSP strongly and concentration dependently inhibited <i>α</i>-glucosidase by functioning as a competitive inhibitor with IC<sub>50</sub> value of 0.67 ± 0.44 ...[more]