Effects of moderate, voluntary ethanol consumption on the rat and human gut microbiome.

ABSTRACT: Many alcohol-induced health complications are directly attributable to the toxicity of alcohol or its metabolites, but another potential health impact of alcohol may be on the microbial communities of the human gut. Clear distinctions between healthy and diseased-state gut microbiota have been observed in subjects with metabolic diseases, and recent studies suggest that chronic alcoholism is linked to gut microbiome dysbiosis. Here, we investigated the effects of moderate levels of alcohol consumption on the gut microbiome in both rats and humans. The gut microbiota of rats voluntarily consuming a 20 percent ethanol solution, on alternate days, were compared with a non-exposed control group to identify differential taxonomic and functional profiles. Gut microbial diversity profiles were de

SUBMITTER: Kosnicki KL 

PROVIDER: S-EPMC6230504 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature