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An Open Resource for Non-human Primate Imaging.

ABSTRACT: Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging given the relatively few centers that have the necessary facilities and capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human primate magnetic resonance imaging (MRI) datasets and openly sharing them via the International Neuroimaging Data-sharing Initiative (INDI). Here, we present the rationale, design, and procedures for the PRIME-DE consortium, as well as the initial release, consisting of 25 independent data collections aggregated across 22 sites (total = 217 non-human primates). We also outline the unique pitfalls and challenges that should be considered in the analysis of non-human primate MRI datasets, including providing automated quality assessment of the contributed datasets.

SUBMITTER: Milham MP

PROVIDER: S-EPMC6231397 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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An Open Resource for Non-human Primate Imaging.

Milham Michael P MP Ai Lei L Koo Bonhwang B Xu Ting T Amiez Céline C Balezeau Fabien F Baxter Mark G MG Blezer Erwin L A ELA Brochier Thomas T Chen Aihua A Croxson Paula L PL Damatac Christienne G CG Dehaene Stanislas S Everling Stefan S Fair Damian A DA Fleysher Lazar L Freiwald Winrich W Froudist-Walsh Sean S Griffiths Timothy D TD Guedj Carole C Hadj-Bouziane Fadila F Ben Hamed Suliann S Harel Noam N Hiba Bassem B Jarraya Bechir B Jung Benjamin B Kastner Sabine S Klink P Christiaan PC Kwok Sze Chai SC Laland Kevin N KN Leopold David A DA Lindenfors Patrik P Mars Rogier B RB Menon Ravi S RS Messinger Adam A Meunier Martine M Mok Kelvin K Morrison John H JH Nacef Jennifer J Nagy Jamie J Rios Michael Ortiz MO Petkov Christopher I CI Pinsk Mark M Poirier Colline C Procyk Emmanuel E Rajimehr Reza R Reader Simon M SM Roelfsema Pieter R PR Rudko David A DA Rushworth Matthew F S MFS Russ Brian E BE Sallet Jerome J Schmid Michael Christoph MC Schwiedrzik Caspar M CM Seidlitz Jakob J Sein Julien J Shmuel Amir A Sullivan Elinor L EL Ungerleider Leslie L Thiele Alexander A Todorov Orlin S OS Tsao Doris D Wang Zheng Z Wilson Charles R E CRE Yacoub Essa E Ye Frank Q FQ Zarco Wilbert W Zhou Yong-di YD Margulies Daniel S DS Schroeder Charles E CE

Neuron 20180927 1

Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging given the relatively few centers that have the necessary facilities and capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acqui ...[more]

PMID: 30269990

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Project description:PurposeSoluble epoxide hydrolase (sEH) is a promising candidate positron emission tomography (PET) imaging biomarker altered in various disorders, including vascular cognitive impairment (VCI), Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and depression, known to regulate levels of epoxyeicosatrienoic acids (EETs) and play an important role in neurovascular coupling. [18F]FNDP, a PET radiotracer for imaging sEH, was evaluated through quantitative PET imaging in the baboon brain, radiometabolite analysis, and radiation dosimetry estimate.MethodsBaboon [18F]FNDP dynamic PET studies were performed at baseline and with blocking doses of the selective sEH inhibitor AR-9281 to evaluate sEH binding specificity. Radiometabolites of [18F]FNDP in mice and baboons were measured by high-performance liquid chromatography. Regional brain distribution volume (VT) of [18F]FNDP was computed from PET using radiometabolite-corrected arterial input functions. Full body distribution of [18F]FNDP was studied in CD-1 mice, and the human effective dose was estimated using OLINDA/EXM software.Results[18F]FNDP exhibited high and rapid brain uptake in baboons. AR-9281 blocked [18F]FNDP uptake dose-dependently with a baseline VT of 10.9 ± 2.4 mL/mL and a high-dose blocking VT of 1.0 ± 0.09 mL/mL, indicating substantial binding specificity (91.70 ± 1.74%). The VND was estimated as 0.865 ± 0.066 mL/mL. The estimated occupancy values of AR-9281 were 99.2 ± 1.1% for 1 mg/kg, 88.6 ± 1.3% for 0.1 mg/kg, and 33.8 ± 3.8% for 0.02 mg/kg. Murine biodistribution of [18F]FNDP enabled an effective dose estimate for humans (0.032 mSv/MBq). [18F]FNDP forms hydrophilic radiometabolites in murine and non-human primate plasma. However, only minute amounts of the radiometabolites entered the animal brain (< 2% in mice).Conclusions[18F]FNDP is a highly sEH-specific radiotracer that is suitable for quantitative PET imaging in the baboon brain. [18F]FNDP holds promise for translation to human subjects.

Dataset Information

An Open Resource for Non-human Primate Imaging.

Publications

An Open Resource for Non-human Primate Imaging.

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