Ontology highlight
ABSTRACT:
SUBMITTER: Menon V
PROVIDER: S-EPMC6232166 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Frontiers in cardiovascular medicine 20181106
Heart valves are dynamic, highly organized structures required for unidirectional blood flow through the heart. Over an average lifetime, the valve leaflets or cusps open and close over a billion times, however in over 5 million Americans, leaflet function fails due to biomechanical insufficiency in response to wear-and-tear or pathological stimulus. Calcific aortic valve disease (CAVD) is the most common valve pathology and leads to stiffening of the cusp and narrowing of the aortic orifice lea ...[more]