Monogenic Lupus: A Developing Paradigm of Disease.
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ABSTRACT:
SUBMITTER: Alperin JM
PROVIDER: S-EPMC6232876 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Monogenic Lupus: A Developing Paradigm of Disease.
Alperin Jessie M JM Ortiz-Fernández Lourdes L Sawalha Amr H AH
Frontiers in immunology 20181030
Monogenic lupus is a form of systemic lupus erythematosus (SLE) that occurs in patients with a single gene defect. This rare variant of lupus generally presents with early onset severe disease, especially affecting the kidneys and central nervous system. To date, a significant number of genes have been implicated in monogenic lupus, providing valuable insights into a very complex disease process. Throughout this review, we will summarize the genes reported to be associated with monogenic lupus o ...[more]
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