Ontology highlight
ABSTRACT:
SUBMITTER: Jayson CBK
PROVIDER: S-EPMC6232964 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Jayson Christina B K CBK Arlt Henning H Fischer Alexander W AW Lai Zon Weng ZW Farese Robert V RV Walther Tobias C TC
Molecular biology of the cell 20180627 17
Rab GTPases recruit peripheral membrane proteins and can define organelle identity. Rab18 localizes to the endoplasmic reticulum (ER) but also to lipid droplets (LDs), where it has been implicated in effector protein recruitment and in defining LD identity. Here, we studied Rab18 localization and function in a human mammary carcinoma cell line. Rab18 localized to the ER and to LD membranes on LD induction, with the latter depending on the Rab18 activation state. In cells lacking Rab18, LDs were ...[more]