Ontology highlight
ABSTRACT:
SUBMITTER: Kang PJ
PROVIDER: S-EPMC6233053 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Kang Pil Jung PJ Miller Kristi E KE Guegueniat Julia J Beven Laure L Park Hay-Oak HO
Molecular biology of the cell 20180809 20
The Cdc42 GTPase plays a central role in polarity development in many species. In budding yeast, Cdc42 is essential for polarized growth at the proper site and also for spontaneous cell polarization in the absence of spatial cues. Cdc42 polarization is critical for multiple events in the G1 phase prior to bud emergence, including bud-site assembly, polarization of the actin cytoskeleton, and septin filament assembly to form a ring at the new bud site. Yet the mechanism by which Cdc42 polarizes i ...[more]