Ontology highlight
ABSTRACT:
SUBMITTER: Roa J
PROVIDER: S-EPMC6233121 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Roa Juan J Barroso Alexia A Ruiz-Pino Francisco F Vázquez Maria Jesus MJ Seoane-Collazo Patricia P Martínez-Sanchez Noelia N García-Galiano David D Ilhan Tuncay T Pineda Rafael R León Silvia S Manfredi-Lozano Maria M Heras Violeta V Poutanen Matti M Castellano Juan M JM Gaytan Francisco F Diéguez Carlos C Pinilla Leonor L López Miguel M Tena-Sempere Manuel M
Proceedings of the National Academy of Sciences of the United States of America 20181022 45
Conditions of metabolic distress, from malnutrition to obesity, impact, via as yet ill-defined mechanisms, the timing of puberty, whose alterations can hamper later cardiometabolic health and even life expectancy. AMP-activated protein kinase (AMPK), the master cellular energy sensor activated in conditions of energy insufficiency, has a major central role in whole-body energy homeostasis. However, whether brain AMPK metabolically modulates puberty onset remains unknown. We report here that cent ...[more]