Ontology highlight
ABSTRACT:
SUBMITTER: Bethune MT
PROVIDER: S-EPMC6233129 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Bethune Michael T MT Li Xiao-Hua XH Yu Jiaji J McLaughlin Jami J Cheng Donghui D Mathis Colleen C Moreno Blanca Homet BH Woods Katherine K Knights Ashley J AJ Garcia-Diaz Angel A Wong Stephanie S Hu-Lieskovan Siwen S Puig-Saus Cristina C Cebon Jonathan J Ribas Antoni A Yang Lili L Witte Owen N ON Baltimore David D
Proceedings of the National Academy of Sciences of the United States of America 20181022 45
Tumor-specific T cell receptor (TCR) gene transfer enables specific and potent immune targeting of tumor antigens. Due to the prevalence of the HLA-A2 MHC class I supertype in most human populations, the majority of TCR gene therapy trials targeting public antigens have employed HLA-A2-restricted TCRs, limiting this approach to those patients expressing this allele. For these patients, TCR gene therapy trials have resulted in both tantalizing successes and lethal adverse events, underscoring the ...[more]