Integration of Drosophila and Human Genetics to Understand Notch Signaling Related Diseases.

ABSTRACT: Notch signaling research dates back to more than one hundred years, beginning with the identification of the Notch mutant in the fruit fly Drosophila melanogaster. Since then, research on Notch and related genes in flies has laid the foundation of what we now know as the Notch signaling pathway. In the 1990s, basic biological and biochemical studies of Notch signaling components in mammalian systems, as well as identification of rare mutations in Notch signaling pathway genes in human patients with rare Mendelian diseases or cancer, increased the significance of this pathway in human biology and medicine. In the 21^st century, Drosophila and other genetic model organisms continue to play a leading role in understanding basic Notch biology. Furthermore, these model organisms can b

SUBMITTER: Salazar JL 

PROVIDER: S-EPMC6233323 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature