Self-Reporting Chemically Induced Protein Proximity System Based on a Malachite Green Derivative and the L5** Fluorogen Activating Protein.
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ABSTRACT:
SUBMITTER: Zeng G
PROVIDER: S-EPMC6233874 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Self-Reporting Chemically Induced Protein Proximity System Based on a Malachite Green Derivative and the L5** Fluorogen Activating Protein.
Zeng Guihua G Wang Yi Y Bruchez Marcel P MP Liang Fu-Sen FS
Bioconjugate chemistry 20180820 9
A unique chemically induced proximity method is engineered based on mutant antibody VL domain using a fluorogenic malachite green derivative as the inducer, which gives fluorescent signals upon VL domain dimerization while simultaneously inducing downstream biological effects. ...[more]
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