(Radio)fluoroclick Reaction Enabled by a Hydrogen-Bonding Cluster.
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ABSTRACT:
SUBMITTER: Zeng X
PROVIDER: S-EPMC6233894 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
(Radio)fluoroclick Reaction Enabled by a Hydrogen-Bonding Cluster.
Zeng Xiaojun X Li Junling J Ng Chin K CK Hammond Gerald B GB Xu Bo B
Angewandte Chemie (International ed. in English) 20180213 11
We have developed a widely applicable nucleophilic (radio)fluoroclick reaction of ynamides with readily available and easy-to-handle KF(<sup>18</sup> F). The reactions exhibited high functional-group tolerance and needed only an ambient atmosphere. This <sup>18</sup> F addition to C-C unsaturated bonds proceeded with extraordinarily high radiochemical yields. ...[more]
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