Ontology highlight
ABSTRACT:
SUBMITTER: Feng X
PROVIDER: S-EPMC6234025 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Feng Xi X Liu Sharon S Chen David D Rosi Susanna S Gupta Nalin N
eLife 20181113
More than half of long-term brain tumor survivors develop irreversible cognitive decline that severely affect their quality of life. However, there is no pre-clinical model that allows long-term assessment of cognition, and there is no treatment which ameliorates cognitive deficits in patients. Here, we report a novel glioma mouse model that offers manageable tumor growth and reliable assessment of cognitive functions in a post-treatment manner. Using this model, we found that fractionated whole ...[more]