Ontology highlight
ABSTRACT:
SUBMITTER: Salisbury-Ruf CT
PROVIDER: S-EPMC6234033 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Salisbury-Ruf Christi T CT Bertram Clinton C CC Vergeade Aurelia A Lark Daniel S DS Shi Qiong Q Heberling Marlene L ML Fortune Niki L NL Okoye G Donald GD Jerome W Gray WG Wells Quinn S QS Fessel Josh J Moslehi Javid J Chen Heidi H Roberts L Jackson LJ Boutaud Olivier O Gamazon Eric R ER Zinkel Sandra S SS
eLife 20181003
Bcl-2 family proteins reorganize mitochondrial membranes during apoptosis, to form pores and rearrange cristae. In vitro and in vivo analysis integrated with human genetics reveals a novel homeostatic mitochondrial function for Bcl-2 family protein Bid. Loss of full-length Bid results in apoptosis-independent, irregular cristae with decreased respiration. <i>Bid-/-</i> mice display stress-induced myocardial dysfunction and damage. A gene-based approach applied to a biobank, validated in two inde ...[more]