Rapid and quantitative chemical exchange saturation transfer (CEST) imaging with magnetic resonance fingerprinting (MRF).

ABSTRACT: PURPOSE:To develop a fast magnetic resonance fingerprinting (MRF) method for quantitative chemical exchange saturation transfer (CEST) imaging. METHODS:We implemented a CEST-MRF method to quantify the chemical exchange rate and volume fraction of the N? -amine protons of L-arginine (L-Arg) phantoms and the amide and semi-solid exchangeable protons of in vivo rat brain tissue. L-Arg phantoms were made with different concentrations (25-100?mM) and pH (pH?4-6). The MRF acquisition schedule varied the saturation power randomly for 30 iterations (phantom: 0-6??T; in vivo: 0-4??T) with a total acquisition time of ?2?min. The signal trajectories were pattern-matched to a large dictionary of signal trajectories simulated using the Bloch-McConnell equations for different combinations of exchange rate, exchangeable proton volume fraction, and water T1 and T2 relaxation times. RESULTS:The chemical exchange rates of the N? -amine protons of L-Arg were significantly (P?

SUBMITTER: Cohen O 

PROVIDER: S-EPMC6234098 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature