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A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults.


ABSTRACT: Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2?g gluten per day) and a high-gluten diet (18?g gluten per day), separated by a washout period of at least six weeks with habitual diet (12?g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.

SUBMITTER: Hansen LBS 

PROVIDER: S-EPMC6234216 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults.

Hansen Lea B S LBS   Roager Henrik M HM   Søndertoft Nadja B NB   Gøbel Rikke J RJ   Kristensen Mette M   Vallès-Colomer Mireia M   Vieira-Silva Sara S   Ibrügger Sabine S   Lind Mads V MV   Mærkedahl Rasmus B RB   Bahl Martin I MI   Madsen Mia L ML   Havelund Jesper J   Falony Gwen G   Tetens Inge I   Nielsen Trine T   Allin Kristine H KH   Frandsen Henrik L HL   Hartmann Bolette B   Holst Jens Juul JJ   Sparholt Morten H MH   Holck Jesper J   Blennow Andreas A   Moll Janne Marie JM   Meyer Anne S AS   Hoppe Camilla C   Poulsen Jørgen H JH   Carvalho Vera V   Sagnelli Domenico D   Dalgaard Marlene D MD   Christensen Anders F AF   Lydolph Magnus Christian MC   Ross Alastair B AB   Villas-Bôas Silas S   Brix Susanne S   Sicheritz-Pontén Thomas T   Buschard Karsten K   Linneberg Allan A   Rumessen Jüri J JJ   Ekstrøm Claus T CT   Ritz Christian C   Kristiansen Karsten K   Nielsen H Bjørn HB   Vestergaard Henrik H   Færgeman Nils J NJ   Raes Jeroen J   Frøkiær Hanne H   Hansen Torben T   Lauritzen Lotte L   Gupta Ramneek R   Licht Tine Rask TR   Pedersen Oluf O  

Nature communications 20181113 1


Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout pe  ...[more]

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