Ontology highlight
ABSTRACT:
SUBMITTER: Perriot S
PROVIDER: S-EPMC6234919 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Perriot Sylvain S Mathias Amandine A Perriard Guillaume G Canales Mathieu M Jonkmans Nils N Merienne Nicolas N Meunier Cécile C El Kassar Lina L Perrier Anselme L AL Laplaud David-Axel DA Schluep Myriam M Déglon Nicole N Du Pasquier Renaud R
Stem cell reports 20181025 5
Recent studies highlighted the importance of astrocytes in neuroinflammatory diseases, interacting closely with other CNS cells but also with the immune system. However, due to the difficulty in obtaining human astrocytes, their role in these pathologies is still poorly characterized. Here, we develop a serum-free protocol to differentiate human induced pluripotent stem cells (hiPSCs) into astrocytes. Gene expression and functional assays show that our protocol consistently yields a highly enric ...[more]