Ontology highlight
ABSTRACT:
SUBMITTER: Tam A
PROVIDER: S-EPMC6235719 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Tam Allison A Chen Shan S Schauer Evan E Grafe Ingo I Bandi Venkata V Shapiro Jay R JR Steiner Robert D RD Smith Peter A PA Bober Michael B MB Hart Tracy T Cuthbertson David D Krischer Jeffrey J Mullins Mary M Byers Peter H PH Sandhaus Robert A RA Durigova Michaela M Glorieux Francis H FH Rauch Frank F Reid Sutton Vernon V Lee Brendan B Rush Eric T ET Nagamani Sandesh C S SCS
Clinical genetics 20180924 6
Pulmonary complications are a significant cause for morbidity and mortality in osteogenesis imperfecta (OI). However, to date, there have been few studies that have systematically evaluated pulmonary function in individuals with OI. We analyzed spirometry measurements, including forced vital capacity (FVC) and forced expiratory volume in the first second (FEV<sub>1</sub> ), in a large cohort of individuals with OI (n = 217) enrolled in a multicenter, observational study. We show that individuals ...[more]