Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC6235766 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Zhou Yuan Y Wang Qian Q Yang Qi Q Tang Jielin J Xu Chonghui C Gai Dongwei D Chen Xinwen X Chen Jizheng J
Virologica Sinica 20181017 5
Histone deacetylase (HDAC) inhibitors show clinical promise for the treatment of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the effect of HDAC inhibitor treatment on hepatitis C virus (HCV) replication in Huh7 human liver cells and in a mouse model of HCV infection. Viral replication was markedly suppressed by the HDAC3 inhibitor at concentrations below 1 mmol/L, with no cellular toxicity. This was accompanied by upregulation of liver-expressed antimicrobia ...[more]