Clinical significance of APOB inactivation in hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Lee G
PROVIDER: S-EPMC6235894 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Clinical significance of APOB inactivation in hepatocellular carcinoma.
Lee Gena G Jeong Yun Seong YS Kim Do Won DW Kwak Min Jun MJ Koh Jiwon J Joo Eun Wook EW Lee Ju-Seog JS Kah Susie S Sim Yeong-Eun YE Yim Sun Young SY
Experimental & molecular medicine 20181114 11
Recent findings from The Cancer Genome Atlas project have provided a comprehensive map of genomic alterations that occur in hepatocellular carcinoma (HCC), including unexpected mutations in apolipoprotein B (APOB). We aimed to determine the clinical significance of this non-oncogenetic mutation in HCC. An Apob gene signature was derived from genes that differed between control mice and mice treated with siRNA specific for Apob (1.5-fold difference; P < 0.005). Human gene expression data were col ...[more]
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