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Clinical significance of APOB inactivation in hepatocellular carcinoma.


ABSTRACT: Recent findings from The Cancer Genome Atlas project have provided a comprehensive map of genomic alterations that occur in hepatocellular carcinoma (HCC), including unexpected mutations in apolipoprotein B (APOB). We aimed to determine the clinical significance of this non-oncogenetic mutation in HCC. An Apob gene signature was derived from genes that differed between control mice and mice treated with siRNA specific for Apob (1.5-fold difference; P?

SUBMITTER: Lee G 

PROVIDER: S-EPMC6235894 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Clinical significance of APOB inactivation in hepatocellular carcinoma.

Lee Gena G   Jeong Yun Seong YS   Kim Do Won DW   Kwak Min Jun MJ   Koh Jiwon J   Joo Eun Wook EW   Lee Ju-Seog JS   Kah Susie S   Sim Yeong-Eun YE   Yim Sun Young SY  

Experimental & molecular medicine 20181114 11


Recent findings from The Cancer Genome Atlas project have provided a comprehensive map of genomic alterations that occur in hepatocellular carcinoma (HCC), including unexpected mutations in apolipoprotein B (APOB). We aimed to determine the clinical significance of this non-oncogenetic mutation in HCC. An Apob gene signature was derived from genes that differed between control mice and mice treated with siRNA specific for Apob (1.5-fold difference; P < 0.005). Human gene expression data were col  ...[more]

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