Ontology highlight
ABSTRACT:
SUBMITTER: Seccia TM
PROVIDER: S-EPMC6236434 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Seccia Teresa M TM Caroccia Brasilina B Gomez-Sanchez Elise P EP Gomez-Sanchez Celso E CE Rossi Gian Paolo GP
Endocrine reviews 20181201 6
The identification of several germline and somatic ion channel mutations in aldosterone-producing adenomas (APAs) and detection of cell clusters that can be responsible for excess aldosterone production, as well as the isolation of autoantibodies activating the angiotensin II type 1 receptor, have rapidly advanced the understanding of the biology of primary aldosteronism (PA), particularly that of APA. Hence, the main purpose of this review is to discuss how discoveries of the last decade could ...[more]