Safety analysis in patients with autoimmune disease receiving allogeneic mesenchymal stem cells infusion: a long-term retrospective study.

ABSTRACT:

Objective

The aim of this study was to evaluate the safety of mesenchymal stem cell infusion in patients with autoimmune diseases.

Methods

A total of 404 patients with autoimmune diseases who received mesenchymal stem cell infusion between 2007 and 2016 were included in this study. Adverse events in these patients were collected, mainly including infections and malignancies. Sources of information included hospitalization records and data from outpatient visits and each follow-up.

Results

The mean follow-up period of all patients was 43.4 ± 25.9 months (range 1-109). Majority of stem cells were from the umbilical cord. The most common indications for mesenchymal stem cell infusion were systemic lupus erythematosus, Sjögren's syndrome, and systemic sclerosis. The media

SUBMITTER: Liang J 

PROVIDER: S-EPMC6236873 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature