Ontology highlight
ABSTRACT:
SUBMITTER: McCorvy JD
PROVIDER: S-EPMC6237183 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20180820 9
Serotonin (5-hydroxytryptamine; 5-HT) receptors modulate a variety of physiological processes ranging from perception, cognition and emotion to vascular and smooth muscle contraction, platelet aggregation, gastrointestinal function and reproduction. Drugs that interact with 5-HT receptors effectively treat diseases as diverse as migraine headaches, depression and obesity. Here we present four structures of a prototypical serotonin receptor-the human 5-HT<sub>2B</sub> receptor-in complex with che ...[more]