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Monte Carlo modelling of live-timed anticoincidence (LTAC) counting for Cu-64.

ABSTRACT: The radionuclide copper-64 is a promising candidate for nuclear medicine, but its complex decay creates challenges in the primary standardization of its activity. Monte Carlo simulations of live-timed anticoincidence (LTAC) counting of 64Cu were used to calculate corrections to extrapolation intercepts, resulting in improved activity determinations. A small correction (-0.33%) to the linear extrapolation of LTAC data acquired with a ?-gate over the 1346keV gamma peak was determined. We discuss the physical origin of the correction. We also use experimental data to demonstrate a Monte Carlo scaling that allows for inclusion of data acquired with a ?-gate set over the annihilation photon peak(s).

SUBMITTER: Bergeron DE

PROVIDER: S-EPMC6237201 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Monte Carlo modelling of live-timed anticoincidence (LTAC) counting for Cu-64.

Bergeron Denis E DE Fitzgerald Ryan R

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20170923

The radionuclide copper-64 is a promising candidate for nuclear medicine, but its complex decay creates challenges in the primary standardization of its activity. Monte Carlo simulations of live-timed anticoincidence (LTAC) counting of <sup>64</sup>Cu were used to calculate corrections to extrapolation intercepts, resulting in improved activity determinations. A small correction (-0.33%) to the linear extrapolation of LTAC data acquired with a γ-gate over the 1346keV gamma peak was determined. W ...[more]

PMID: 28974327

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