Ontology highlight
ABSTRACT:
SUBMITTER: Sandgren JA
PROVIDER: S-EPMC6237463 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Sandgren Jeremy A JA Deng Guorui G Linggonegoro Danny W DW Scroggins Sabrina M SM Perschbacher Katherine J KJ Nair Anand R AR Nishimura Taryn E TE Zhang Shao Yang SY Agbor Larry N LN Wu Jing J Keen Henry L HL Naber Meghan C MC Pearson Nicole A NA Zimmerman Kathy A KA Weiss Robert M RM Bowdler Noelle C NC Usachev Yuriy M YM Santillan Donna A DA Potthoff Matthew J MJ Pierce Gary L GL Gibson-Corley Katherine N KN Sigmund Curt D CD Santillan Mark K MK Grobe Justin L JL
JCI insight 20181004 19
Copeptin, a marker of arginine vasopressin (AVP) secretion, is elevated throughout human pregnancies complicated by preeclampsia (PE), and AVP infusion throughout gestation is sufficient to induce the major phenotypes of PE in mice. Thus, we hypothesized a role for AVP in the pathogenesis of PE. AVP infusion into pregnant C57BL/6J mice resulted in hypertension, renal glomerular endotheliosis, intrauterine growth restriction, decreased placental growth factor (PGF), altered placental morphology, ...[more]