Ontology highlight
ABSTRACT:
SUBMITTER: Trias E
PROVIDER: S-EPMC6237484 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Trias Emiliano E King Peter H PH Si Ying Y Kwon Yuri Y Varela Valentina V Ibarburu Sofía S Kovacs Mariángeles M Moura Ivan C IC Beckman Joseph S JS Hermine Olivier O Barbeito Luis L
JCI insight 20181004 19
Neuroinflammation is a recognized pathogenic mechanism underlying motor neuron degeneration in amyotrophic lateral sclerosis (ALS), but the inflammatory mechanisms influencing peripheral motor axon degeneration remain largely unknown. A recent report showed a pathogenic role for c-Kit-expressing mast cells mediating inflammation and neuromuscular junction denervation in muscles from SOD1G93A rats. Here, we have explored whether mast cells infiltrate skeletal muscles in autopsied muscles from ALS ...[more]