Ontology highlight
ABSTRACT:
SUBMITTER: Kinkead HL
PROVIDER: S-EPMC6237485 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Kinkead Heather L HL Hopkins Alexander A Lutz Eric E Wu Annie A AA Yarchoan Mark M Cruz Kayla K Woolman Skylar S Vithayathil Teena T Glickman Laura H LH Ndubaku Chudi O CO McWhirter Sarah M SM Dubensky Thomas W TW Armstrong Todd D TD Jaffee Elizabeth M EM Zaidi Neeha N
JCI insight 20181018 20
Tumor neoantigens arising from somatic mutations in the cancer genome are less likely to be subject to central immune tolerance and are therefore attractive targets for vaccine immunotherapy. We utilized whole-exome sequencing, RNA sequencing (RNASeq), and an in silico immunogenicity prediction algorithm, NetMHC, to generate a neoantigen-targeted vaccine, PancVAX, which was administered together with the STING adjuvant ADU-V16 to mice bearing pancreatic adenocarcinoma (Panc02) cells. PancVAX act ...[more]