Ontology highlight
ABSTRACT:
SUBMITTER: Modinger Y
PROVIDER: S-EPMC6237570 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Mödinger Yvonne Y Rapp Anna A Pazmandi Julia J Vikman Anna A Holzmann Karlheinz K Haffner-Luntzer Melanie M Huber-Lang Markus M Ignatius Anita A
Journal of cellular and molecular medicine 20180924 12
The anaphylatoxin C5a is generated upon activation of the complement system, a crucial arm of innate immunity. C5a mediates proinflammatory actions via the C5a receptor C5aR1 and thereby promotes host defence, but also modulates tissue homeostasis. There is evidence that the C5a/C5aR1 axis is critically involved both in physiological bone turnover and in inflammatory conditions affecting bone, including osteoarthritis, periodontitis, and bone fractures. C5a induces the migration and secretion of ...[more]