Ontology highlight
ABSTRACT:
SUBMITTER: Ma R
PROVIDER: S-EPMC6237591 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Ma Ruye R Zhang Yu Y Wang Wei W Wu Junqing J Yang Qianqian Q Xu Wanling W Jiang Songfu S Han Yixiang Y Yu Kang K Zhang Shenghui S
Journal of cellular and molecular medicine 20180924 12
Accumulating evidence shows that tigecycline, a first-in-class glycylcycline, has potential antitumour properties. Here, we found that tigecycline dramatically inhibited the proliferation of multiple myeloma (MM) cell lines RPMI-8226, NCI-H929 and U266 in a dose and time-dependent manner. Meanwhile, tigecycline also potently impaired the colony formation of these three cell lines. Mechanism analysis found that tigecycline led to cell cycle arrest at G0/G1 with down-regulation of p21, CDK2 and cy ...[more]