Dataset Information

Cytoplasmic Pin1 expression is increased in human cutaneous melanoma and predicts poor prognosis.

ABSTRACT: The prolyl isomerase Pin1 is widely over-expressed or over-activated in cancers and promotes tumorigenesis. The authors investigated the expression level of Pin1 and analyzed the prognostic value of Pin1 expression using a large-scale melanoma tissue microarray study. Two independent sets of tissue microarrays were employed, including 114 melanoma cases in the discovery set and 424 in the validation set (538 cases in total), 32 normal nevi and 86 dysplastic nevi 118 cases of nevi. The subcellular Pin1 expression in different stages of melanocytic lesions and its prognostic significance were studied. High expression (IRS 0-8) of cytoplasmic Pin1 was observed in 3.13%, 8.33%, 16.49% and 22.76% of the biopsies in normal nevi, dysplastic nevi, primary melanoma and metastatic melanoma, respectively. Significant differences for cytoplasmic Pin1 staining were observed between normal nevi and metastatic melanoma (P?=?0.011, ?2 test), between dysplastic nevi and primary melanoma (P?=?0.046, ?2 test) and between dysplastic nevi and metastatic melanoma (P?=?0.016, ?2 test). Kaplan-Meier survival analysis showed that increased cytoplasmic Pin1 expression was associated with a worse 5-year melanoma-specific survival of melanoma (P?

SUBMITTER: Chen X

PROVIDER: S-EPMC6238011 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Cytoplasmic Pin1 expression is increased in human cutaneous melanoma and predicts poor prognosis.

Chen Xin X Liu Xiaosong X Deng Bin B Martinka Magdalena M Zhou Youwen Y Lan Xiaopeng X Cheng Yabin Y

Scientific reports 20181115 1

The prolyl isomerase Pin1 is widely over-expressed or over-activated in cancers and promotes tumorigenesis. The authors investigated the expression level of Pin1 and analyzed the prognostic value of Pin1 expression using a large-scale melanoma tissue microarray study. Two independent sets of tissue microarrays were employed, including 114 melanoma cases in the discovery set and 424 in the validation set (538 cases in total), 32 normal nevi and 86 dysplastic nevi 118 cases of nevi. The subcellula ...[more]

PMID: 30442923

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Dataset Information

Cytoplasmic Pin1 expression is increased in human cutaneous melanoma and predicts poor prognosis.

Publications

Cytoplasmic Pin1 expression is increased in human cutaneous melanoma and predicts poor prognosis.

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