Ontology highlight
ABSTRACT:
SUBMITTER: Stanley GJ
PROVIDER: S-EPMC6238600 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Stanley George J GJ Fassati Ariberto A Hoogenboom Bart W BW
Life science alliance 20180820 4
The nuclear pore complex (NPC) is a proteinaceous assembly that regulates macromolecular transport into and out of the nucleus. Although the structure of its scaffold is being revealed in increasing detail, its transport functionality depends upon an assembly of intrinsically disordered proteins (called FG-Nups) anchored inside the pore's central channel, which have hitherto eluded structural characterization. Here, using high-resolution atomic force microscopy, we provide a structural and nanom ...[more]