Dataset Information
Spinal Progenitor-Laden Bridges Support Earlier Axon Regeneration Following Spinal Cord Injury.
Ontology highlight
ABSTRACT: Impact statement
Spinal cord injury (SCI) results in loss of tissue innervation below the injury. Spinal progenitors have a greater ability to repair the damage and can be injected into the injury, but their regenerative potential is hampered by their poor survival after transplantation. Biomaterials can create a cell delivery platform and generate a more hospitable microenvironment for the progenitors within the injury. In this work, polymeric bridges are used to deliver embryonic spinal progenitors to the injury, resulting in increased progenitor survival and subsequent regeneration and functional recovery, thus demonstrating the importance of combined therapeutic approaches for SCI.
SUBMITTER: Dumont CM
PROVIDER: S-EPMC6238608 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Spinal Progenitor-Laden Bridges Support Earlier Axon Regeneration Following Spinal Cord Injury.
Tissue engineering. Part A 20181019 21-22
<h4>Impact statement</h4>Spinal cord injury (SCI) results in loss of tissue innervation below the injury. Spinal progenitors have a greater ability to repair the damage and can be injected into the injury, but their regenerative potential is hampered by their poor survival after transplantation. Biomaterials can create a cell delivery platform and generate a more hospitable microenvironment for the progenitors within the injury. In this work, polymeric bridges are used to deliver embryonic spina ...[more]