Ontology highlight
ABSTRACT:
SUBMITTER: Pett JP
PROVIDER: S-EPMC6238625 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Pett J Patrick JP Kondoff Matthew M Bordyugov Grigory G Kramer Achim A Herzel Hanspeter H
Life science alliance 20180614 3
Gene regulatory feedback loops generate autonomous circadian rhythms in mammalian tissues. The well-studied core clock network contains many negative and positive regulations. Multiple feedback loops have been discussed as primary rhythm generators but the design principles of the core clock and differences between tissues are still under debate. Here we use global optimization techniques to fit mathematical models to circadian gene expression profiles for different mammalian tissues. It turns o ...[more]