Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC6238722 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Wang Chao C Shi Genbin G Ji Xinhua X
MedChemComm 20180820 11
The RING finger-dependent ubiquitin ligase (E3) gp78, known as the tumor autocrine motility factor receptor, contributes to tumor progression. The protein interacts with its cognate ubiquitin-conjugating enzyme (E2), Ube2g2, <i>via</i> its RING domain and a unique region called G2BR that strongly binds to E2. The binding of G2BR to Ube2g2 allosterically enhances the binding of RING to E2, and the binding of RING triggers the departure of G2BR from E2 also in an allosteric fashion. Targeting thes ...[more]