Ontology highlight
ABSTRACT:
SUBMITTER: Alban TJ
PROVIDER: S-EPMC6238746 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Alban Tyler J TJ Alvarado Alvaro G AG Sorensen Mia D MD Bayik Defne D Volovetz Josephine J Serbinowski Emily E Mulkearns-Hubert Erin E EE Sinyuk Maksim M Hale James S JS Onzi Giovana R GR McGraw Mary M Huang Pengjing P Grabowski Matthew M MM Wathen Connor A CA Ahluwalia Manmeet S MS Radivoyevitch Tomas T Kornblum Harley I HI Kristensen Bjarne W BW Vogelbaum Michael A MA Lathia Justin D JD
JCI insight 20181102 21
Glioblastoma (GBM) remains uniformly lethal, and despite a large accumulation of immune cells in the microenvironment, there is limited antitumor immune response. To overcome these challenges, a comprehensive understanding of GBM systemic immune response during disease progression is required. Here, we integrated multiparameter flow cytometry and mass cytometry TOF (CyTOF) analysis of patient blood to determine changes in the immune system among tumor types and over disease progression. Utilizin ...[more]