Dataset Information

Inflammatory and coagulatory parameters linked to survival in critically ill children with sepsis.

ABSTRACT:

Background

Sepsis is associated with a deflection of inflammatory and coagulative parameters, since some clotting factors are known to be involved in the host's defense against infection and inflammation. These parameters could play a crucial role in the course of sepsis and be used as prognostic markers in critically ill children.

Methods

A total of 250 critically ill pediatric patients diagnosed with sepsis were retrospectively analyzed to identify routinely measured predictors for in-hospital mortality at the peak level of C-reactive protein. Those parameters entered multivariate logistic regression analysis as well as a decision tree for survival.

Results

Multivariate logistic regression analysis revealed fibrinogen, platelets and activated partial thromboplastin time (aPTT) at the peak level of C-reactive protein to be predictors for survival (p?=?0.03, p?=?0.01 and p?=?0.02, respectively). An increase in fibrinogen and platelets is linked to survival, whereas an aPTT prolongation is associated with higher mortality; adjusted odds ratios (95% CI) for an increase of 100 mg/dl in fibrinogen are 1.35 (1.04-1.82) per 50 G/l platelets 1.94 (1.3-3.29) and 0.83 (0.69-0.96) for an aPTT prolongation of 10 s. Decision tree analysis shows that a fibrinogen level below 192 mg/dl (90.9% vs. 13% mortality) is most distinctive in non-survivors.

Conclusions

High levels of fibrinogen and platelets as well as a non-overshooting aPTT are associated with a higher survival rate in pediatric patients with diagnosed sepsis. In particular, hypofibrinogenemia is distinctive for a high mortality rate in septic critically ill children.

SUBMITTER: Niederwanger C

PROVIDER: S-EPMC6240023 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Publications

Inflammatory and coagulatory parameters linked to survival in critically ill children with sepsis.

Niederwanger Christian C Bachler Mirjam M Hell Tobias T Linhart Caroline C Entenmann Andreas A Balog Agnes A Auer Katharina K Innerhofer Petra P

Annals of intensive care 20181116 1

<h4>Background</h4>Sepsis is associated with a deflection of inflammatory and coagulative parameters, since some clotting factors are known to be involved in the host's defense against infection and inflammation. These parameters could play a crucial role in the course of sepsis and be used as prognostic markers in critically ill children.<h4>Methods</h4>A total of 250 critically ill pediatric patients diagnosed with sepsis were retrospectively analyzed to identify routinely measured predictors ...[more]

PMID: 30446841

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Dataset Information

Inflammatory and coagulatory parameters linked to survival in critically ill children with sepsis.

Background

Methods

Results

Conclusions

Publications

Inflammatory and coagulatory parameters linked to survival in critically ill children with sepsis.

Similar Datasets

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