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Non-obstructive intracellular nanolasers.

ABSTRACT: Molecular dyes, plasmonic nanoparticles and colloidal quantum dots are widely used in biomedical optics. Their operation is usually governed by spontaneous processes, which results in broad spectral features and limited signal-to-noise ratio, thus restricting opportunities for spectral multiplexing and sensing. Lasers provide the ultimate spectral definition and background suppression, and their integration with cells has recently been demonstrated. However, laser size and threshold remain problematic. Here, we report on the design, high-throughput fabrication and intracellular integration of semiconductor nanodisk lasers. By exploiting the large optical gain and high refractive index of GaInP/AlGaInP quantum wells, we obtain lasers with volumes 1000-fold smaller than the eukaryotic nucleus (Vlaser?

SUBMITTER: Fikouras AH

PROVIDER: S-EPMC6240115 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Non-obstructive intracellular nanolasers.

Fikouras Alasdair H AH Schubert Marcel M Karl Markus M Kumar Jothi D JD Powis Simon J SJ Di Falco Andrea A Gather Malte C MC

Nature communications 20181116 1

Molecular dyes, plasmonic nanoparticles and colloidal quantum dots are widely used in biomedical optics. Their operation is usually governed by spontaneous processes, which results in broad spectral features and limited signal-to-noise ratio, thus restricting opportunities for spectral multiplexing and sensing. Lasers provide the ultimate spectral definition and background suppression, and their integration with cells has recently been demonstrated. However, laser size and threshold remain probl ...[more]

PMID: 30446665

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